SCHEMBL64499

SCHEMBL64499

CC(=O)Nc1ccc(C(=O)Cl)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.63
TP53 P04637 2/20 0.63
HIF1A Q16665 1/20 0.63
SMN1; SMN2 Q16637 4/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
HTT P42858 1/20 0.61
KMT2A Q03164 6/20 0.59
MEN1 O00255 4/20 0.59
MAPT P10636 2/20 0.59
TDP1 Q9NUW8 1/20 0.59
CA12 O43570 1/20 0.59
BRD4 O60885 1/20 0.59
NR1I2 O75469 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
MB P02144 1/20 0.59
CYP1A1 P04798 1/20 0.59
CA3 P07451 1/20 0.59
CYP3A4 P08684 1/20 0.59
RARG P13631 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL861674 0.83 SMN1; SMN2 (0.84) ALDH1A1SMN1; SMN2L3MBTL1HTTKMT2A
SCHEMBL11426723 0.83 ALDH1A1 (0.59) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL474757 0.82 ALDH1A1 (0.70) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL29623006 0.82 SMN1; SMN2 (0.67) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL24799884 0.80 RXFP1 (0.59) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL4320074 0.80 ALDH1A1 (0.56) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL4320072 0.80 ALDH1A1 (0.56) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1
SCHEMBL19024618 0.80 MAPT (0.59) ALDH1A1TP53HIF1ASMN1; SMN2KMT2A
SCHEMBL14684215 0.80 NPC1 (0.63) TP53SMN1; SMN2L3MBTL1KMT2AMEN1
SCHEMBL2318719 0.80 RAB9A (0.47) ALDH1A1TP53HIF1ASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110698492-A Preparation method of darunavir 雅本化学股份有限公司 2020-01-17 CN claimed
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-10-09 US disclosed
EP-4536653-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME Eisai R&D Management Co., Ltd. (JP) 2025-04-16 EP disclosed
CN-115057855-B Substituted five-membered and six-membered heterocyclic compound, preparation method, pharmaceutical composition and application thereof 厦门大学 2024-04-26 CN disclosed
WO-2023239906-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-12-14 WO disclosed
WO-2023202583-A1 FXR REGULATOR AND USE THEREOF 北京大学 2023-10-26 WO disclosed
CN-116903559-A FXR modulators and uses thereof 北京大学 2023-10-20 CN disclosed
EP-3112343-B1 AMIDE DERIVATIVES UNIV TOHOKU (JP) 2023-03-29 EP disclosed
CN-110997669-B Substituted five-membered and six-membered heterocyclic compound, preparation method thereof, pharmaceutical composition and application thereof 厦门大学 2022-12-27 CN disclosed
CN-110885296-B Preparation method of bromfenac sodium 新发药业有限公司 2022-11-04 CN disclosed
EP-0332387-A1 Triazole derivatives, their preparation and their use as fungicides Sankyo Company Limited (JP) 1989-09-13 EP disclosed
EP-0260675-A1 4-[N-(substituted)-aminophenyl]-substituted 1,4-di-(hydro)-pyridine derivatives, process for their preparation and medicaments containing them ALKALOIDA VEGYESZETI GYAR (HU) 1988-03-23 EP disclosed
EP-0063261-A2 Cationic azo dyestuffs, their preparation and their use BAYER AG (DE) 1982-10-27 EP disclosed
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-4207327-A N-(4-Pyrazolidinyl)benzamides and their amino precursors A. H. ROBINS COMPANY, INC. (US) 1980-06-10 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed
US-4069224-A N-(PYRIDYLALKYL)BENZAMIDES, IMPROVE PRODUCTION OF PROSTAGLANDINS IN MAMMALS THE UPJOHN COMPANY (US) 1978-01-17 US disclosed
US-4007190-A ANTITUMOR, MICROBIOCIDE MERCK & CO., INC. (US) 1977-02-08 US disclosed
US-3954852-A Indenylacetic acid compounds MERCK & CO., INC. (US) 1976-05-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250313574-A1 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME NEU1, NEU2, NEU4 ALDH1A1 474/4885TP53 3278/4885HIF1A 1462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.