SCHEMBL6450540

SCHEMBL6450540

CCC(C)C=Cc1cccnc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.53
CHRNA4 P43681 2/20 0.53
CYP11B1 P15538 1/20 0.52
CYP11B2 P19099 1/20 0.52
ALOX5 P09917 3/20 0.49
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
CHRNB4 P30926 1/20 0.47
CHRNA3 P32297 1/20 0.47
CHRNA7 P36544 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
ALOX15 P16050 1/20 0.47
CYP2C19 P33261 1/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
MAPT P10636 2/20 0.46
MAPK1 P28482 2/20 0.46
KDM4E B2RXH2 1/20 0.46
JUN P05412 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23640127 0.87 CHRNB2 (0.50) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL3017116 0.85 CHRNB2 (0.51) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL3017118 0.85 CHRNB2 (0.51) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL9341849 0.82 CHRNB2 (0.47) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL3023719 0.82 CHRNB2 (0.56) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL6268339 0.82 CHRNB2 (0.56) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL3023723 0.82 CHRNB2 (0.56) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL6450487 0.82 CYP11B1 (0.59) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL9967696 0.82 CYP11B1 (0.59) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5
SCHEMBL19103056 0.82 CHRNB2 (0.46) CHRNB2CHRNA4CYP11B1CYP11B2ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1556352-A1 COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2005-07-27 EP disclosed
WO-2004031151-A1 COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2004-04-15 WO disclosed
EP-1086082-A1 ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS R.J. REYNOLDS TOBACCO COMPANY (US) 2001-03-28 EP disclosed
WO-1999065876-A1 ARYL SUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS R.J. REYNOLDS TOBACCO COMPANY (US) 1999-12-23 WO disclosed