Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | SELL | P14151 | 1/20 | 0.45 |
| ▸ | SELP | P16109 | 1/20 | 0.45 |
| ▸ | SELE | P16581 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425495 | 0.87 | MMP12 (0.58) | ALDH1A1LMNAMMP12KMT2AHDAC1 | |
| SCHEMBL6451885 | 0.86 | MMP12 (0.68) | NR1H4EPHX2ALDH1A1LMNAMMP12 | |
| SCHEMBL6667189 | 0.82 | HTT (0.52) | ALDH1A1LMNAMMP12KMT2AMAPK1 | |
| SCHEMBL6882993 | 0.77 | MMP12 (0.48) | ALDH1A1LMNAMMP12KMT2AMAPK1 | |
| SCHEMBL6455464 | 0.76 | NPC1 (0.61) | NR1H4EPHX2ALDH1A1MMP12KMT2A | |
| SCHEMBL6527574 | 0.76 | MMP12 (0.60) | NR1H4EPHX2MMP12KMT2AHDAC1 | |
| SCHEMBL6871411 | 0.76 | NR1H4 (0.67) | NR1H4EPHX2LMNAMMP12KMT2A | |
| SCHEMBL6245871 | 0.76 | NR1H4 (0.71) | NR1H4EPHX2ALDH1A1KMT2AHDAC1 | |
| SCHEMBL6663858 | 0.74 | MMP12 (0.59) | NR1H4EPHX2MMP12MAPK1MMP13 | |
| SCHEMBL14508841 | 0.73 | HDAC6 (0.69) | NR1H4EPHX2KMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1394159-A1 | New thiophene derivatives, process for their preparation and pharmaceutical compositions containing them | Warner-Lambert Company LLC (US) | 2004-03-03 | — | — | EP | disclosed |