Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425495 | 0.87 | MMP12 (0.58) | MMP12ALDH1A1LMNAL3MBTL1MAPK1 | |
| SCHEMBL6450604 | 0.86 | NR1H4 (0.52) | MMP12ALDH1A1LMNAEPHX2NR1H4 | |
| SCHEMBL6451966 | 0.83 | KMT2A (0.62) | MMP12ALDH1A1LMNANR1H4SMN1; SMN2 | |
| SCHEMBL6882993 | 0.82 | MMP12 (0.48) | MMP12ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL6880697 | 0.77 | MMP12 (0.78) | MMP12ALDH1A1LMNAEPHX2NR1H4 | |
| SCHEMBL6667189 | 0.77 | HTT (0.52) | MMP12ALDH1A1LMNAL3MBTL1MAPK1 | |
| SCHEMBL6874960 | 0.76 | MMP12 (0.77) | MMP12ALDH1A1LMNAEPHX2NR1H4 | |
| SCHEMBL8342537 | 0.76 | MMP12 (0.77) | MMP12ALDH1A1LMNAEPHX2NR1H4 | |
| SCHEMBL8341227 | 0.76 | MMP12 (0.77) | MMP12ALDH1A1MAPK1SMN1; SMN2HPGD | |
| SCHEMBL6874687 | 0.76 | MMP12 (0.83) | MMP12LMNAEPHX2SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |