Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6ST | P40189 | 5/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | MLYCD | O95822 | 10/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211410 | 1.00 | IL6ST (0.45) | IL6STSTAT3PIK3CDIDH1MLYCD | |
| SCHEMBL8211407 | 1.00 | IL6ST (0.45) | IL6STSTAT3PIK3CDIDH1MLYCD | |
| SCHEMBL8211409 | 1.00 | IL6ST (0.45) | IL6STSTAT3PIK3CDIDH1MLYCD | |
| SCHEMBL7280251 | 0.87 | IL6ST (0.43) | IL6STSTAT3PIK3CDIDH1PLA2G10 | |
| SCHEMBL7280258 | 0.87 | IL6ST (0.43) | IL6STSTAT3PIK3CDIDH1PLA2G10 | |
| SCHEMBL7280265 | 0.87 | IL6ST (0.43) | IL6STSTAT3PIK3CDIDH1PLA2G10 | |
| SCHEMBL7344045 | 0.86 | IL6ST (0.48) | IL6STSTAT3PIK3CDIDH1MLYCD | |
| SCHEMBL8634121 | 0.86 | IL6ST (0.48) | IL6STSTAT3PIK3CDIDH1MLYCD | |
| SCHEMBL7428550 | 0.86 | IL6ST (0.45) | IL6STSTAT3PIK3CDPLA2G10PLA2G5 | |
| SCHEMBL8218741 | 0.86 | IL6ST (0.52) | IL6STSTAT3PIK3CDPLA2G10PLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-B1 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LAB (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |