Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALAD | P13716 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 3/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505511 | 0.84 | ALAD (0.70) | ALADHDAC6DAOMMP12MEN1 | |
| SCHEMBL1800477 | 0.83 | ALAD (0.69) | ALADHDAC6DAOALDH1A1MMP12 | |
| SCHEMBL6143622 | 0.83 | ALAD (0.69) | ALADHDAC6DAOMMP3MMP12 | |
| SCHEMBL2652069 | 0.83 | ALAD (1.00) | ALADHDAC6DAOMMP12MEN1 | |
| SCHEMBL3625585 | 0.83 | ALAD (0.69) | ALADHDAC6DAOBCL2L1MMP12 | |
| SCHEMBL6142253 | 0.83 | ALAD (0.69) | ALADHDAC6DAOCYP3A4ALDH1A1 | |
| SCHEMBL6142121 | 0.83 | ALAD (1.00) | ALADHDAC6DAOALDH1A1MMP12 | |
| SCHEMBL6882926 | 0.82 | ALAD (0.50) | ALADHDAC6HSD17B1HSD17B2CYP3A4 | |
| SCHEMBL4381926 | 0.81 | ALAD (0.66) | ALADHDAC6DAOMMP3MMP12 | |
| SCHEMBL3641638 | 0.80 | HSD17B1 (0.59) | ALADHDAC6DAOHSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1394159-A1 | New thiophene derivatives, process for their preparation and pharmaceutical compositions containing them | Warner-Lambert Company LLC (US) | 2004-03-03 | — | — | EP | disclosed |