Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24037264 | 0.81 | KDM4E (0.50) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL6448287 | 0.72 | HTT (0.48) | KDM4EHPGDHSD17B10ALDH1A1MEN1 | |
| SCHEMBL21859026 | 0.72 | LMNA (0.56) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL11512749 | 0.71 | KDM4E (0.51) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL3316768 | 0.70 | KDM4E (0.41) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL12485231 | 0.69 | KDM4E (0.45) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL3006540 | 0.69 | KDM4E (0.68) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL1312979 | 0.68 | POLB (0.57) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL11236984 | 0.68 | KDM4E (0.72) | KDM4EHPGDHSD17B10ALDH1A1TSHR | |
| SCHEMBL1661468 | 0.67 | LMNA (0.71) | KDM4EHPGDHSD17B10ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004364-A1 | Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides and purification of 1,5-naphthyridine-3-carboxyamides | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004106336-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF 1,5-NAPHTHYRIDINE-3-CARBOXYAMIDES | PFIZER PRODUCTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004364-A1 | Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides and purification of 1,5-naphthyridine-3-carboxyamides | TNS4, CHRNA5, CHRNA2 | KDM4E 891/4885HPGD 2789/4885HSD17B10 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.