SCHEMBL6452082

SCHEMBL6452082

CC1CC[C@@H]2C[C@H](c3ccc(-c4cc(F)c(Cl)c(F)c4)c(F)c3)CC[C@@H]2C1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FASN P49327 1/20 0.36
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
APP P05067 1/20 0.31
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6452085 1.00 FASN (0.36) FASNCYP3A4CYP2C9APPPDK2
SCHEMBL6453235 0.90 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL6453237 0.90 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL6453700 0.88 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL6453704 0.88 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL6464284 0.88 FASN (0.40) FASNCYP3A4CYP2C9APP
SCHEMBL6464288 0.88 FASN (0.40) FASNCYP3A4CYP2C9APP
SCHEMBL6457441 0.87 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL6457436 0.87 FASN (0.37) FASNCYP3A4CYP2C9APP
SCHEMBL14206983 0.87 FASN (0.41) FASNCYP3A4CYP2C9APPPDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6913797-B1 Decahydronaphthalene derivative DAINIPPON INK AND CHEMICALS, INC. (JP) 2005-07-05 US disclosed
EP-1108700-A1 DECAHYDRONAPHTHALENE DERIVATIVE DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-06-20 EP disclosed