SCHEMBL6452272

SCHEMBL6452272

COc1ccc(-c2cc(-c3ccc(Cl)cc3)n(-c3ccc(S(N)(=O)=O)cc3)n2)cc1.Cc1ccc(-c2cc(-c3ccc(C)cc3)n(-c3ccc(S(N)(=O)=O)cc3)n2)cc1

nearest known ligand 0.92

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 16/20 0.92
PTGS1 P23219 4/20 0.92
CYP2C9 P11712 1/20 0.70
CA1 P00915 1/20 0.60
CA2 P00918 1/20 0.60
CA9 Q16790 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.59
CHRNA7 P36544 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL213881 0.96 PTGS2 (1.00) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL8113323 0.96 PTGS2 (1.00) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL212983 0.93 PTGS2 (0.83) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL8121503 0.93 PTGS2 (0.83) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL216745 0.90 PTGS2 (0.89) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL212919 0.87 CYP2C9 (0.90) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL5698697 0.87 PTGS2 (0.88) PTGS2PTGS1CYP2C9SMN1; SMN2CHRNA7
SCHEMBL8422275 0.86 PTGS2 (0.82) PTGS2PTGS1CYP2C9
SCHEMBL18826381 0.86 PTGS2 (0.82) PTGS2PTGS1CYP2C9CA1CA2
SCHEMBL8423896 0.86 PTGS2 (0.82) PTGS2PTGS1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833622-B8 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR SEARLE & CO (US) 2005-10-12 EP claimed
JP-2001503395-A 2001-03-13 JP claimed
EP-0932402-A1 METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA G.D. SEARLE & CO. (US) 1999-08-04 EP claimed
WO-1998016227-A9 METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA 1998-07-30 WO claimed
WO-1998016227-A1 METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE TREATMENT AND PREVENTION OF NEOPLASIA G.D. SEARLE & CO. (US) 1998-04-23 WO claimed
EP-0833622-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1998-04-08 EP claimed
WO-1996041626-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1996-12-27 WO claimed
EP-0833622-B8 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR SEARLE & CO (US) 2005-10-12 EP disclosed
EP-0833622-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1998-04-08 EP disclosed
WO-1996041626-A1 COMPOSITIONS COMPRISING A CYCLOOXYGENASE-2 INHIBITOR AND A 5-LIPOXYGENASE INHIBITOR G.D. SEARLE & CO. (US) 1996-12-27 WO disclosed