Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.40 |
| ▸ | PDE4A | P27815 | 8/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453982 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDGFRB | |
| SCHEMBL6453976 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDGFRB | |
| SCHEMBL5563183 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL5563191 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL5563196 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL6449710 | 0.79 | RPS6KB2 (0.41) | PDE4DPDGFRBPDGFRAHTTMEN1 | |
| SCHEMBL6449709 | 0.79 | RPS6KB2 (0.41) | PDE4DPDGFRBPDGFRAHTTMEN1 | |
| SCHEMBL6442469 | 0.79 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CCYP1A2 | |
| SCHEMBL6442473 | 0.79 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CCYP1A2 | |
| SCHEMBL6449706 | 0.79 | RPS6KB2 (0.41) | PDE4DPDGFRBPDGFRAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884802-B2 | 6-heteroarylphenanthridines | ALTANA PHARMA AG (DE) | 2005-04-26 | — | — | US | disclosed |
| US-20040038979-A1 | Treating airway disorders such as asthma. | ALTANA PHARMA AG (DE) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038979-A1 | Treating airway disorders such as asthma. | PTGER4, PDE4B, PDE4A | PDE4D 20/4885PDE4A 3/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.