SCHEMBL645440

SCHEMBL645440

COc1ccc(C(c2ccc(Nc3ccccc3)cc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.63
MAPT P10636 6/20 0.63
NPC1 O15118 4/20 0.63
MAPK1 P28482 4/20 0.63
TDP1 Q9NUW8 4/20 0.63
KDM4E B2RXH2 3/20 0.63
L3MBTL1 Q9Y468 3/20 0.63
GAA P10253 3/20 0.63
THRB P10828 2/20 0.63
RECQL P46063 2/20 0.63
NPSR1 Q6W5P4 2/20 0.63
ALDH1A1 P00352 6/20 0.54
KMT2A Q03164 4/20 0.54
MEN1 O00255 3/20 0.54
NR4A1 P22736 1/20 0.53
ALOX12 P18054 2/20 0.53
HSD17B10 Q99714 2/20 0.53
KCNH3 Q9ULD8 1/20 0.53
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8205697 0.89 MAPT (0.53) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL9479393 0.88 RAB9A (0.81) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL316390 0.88 RAB9A (0.81) RAB9AMAPTNPC1MAPK1TDP1
Hydrochloric Acid SCHEMBL7128947 0.86 RAB9A (0.77) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL34971 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL14205685 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL13295535 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL40557 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL13295540 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1
SCHEMBL13295537 0.84 SLC2A1 (0.61) RAB9AMAPTNPC1MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119317-B2 Electrophotographic photoreceptor, and process cartridge and image forming apparatus using the photoreceptor RICOH COMPANY, LTD. (JP) 2012-02-21 US disclosed
US-8043777-B2 Electrophotographic photoconductor, process cartridge, and image forming apparatus RICOH COMPANY, LTD. (JP) 2011-10-25 US disclosed
US-20090067891-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2009-03-12 US disclosed
US-20080311499-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, AND PROCESS CARTRIDGE AND IMAGE FORMING APPARATUS USING THE PHOTORECEPTOR RICOH COMPANY, LTD. (JP) 2008-12-18 US disclosed
US-20080085459-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, AND ELECTROPHOTOGRAPHIC APPARATUS RICOH COMPANY, LTD. (JP) 2008-04-10 US disclosed