SCHEMBL6454987

SCHEMBL6454987

CC1(C)CC(=O)Nc2ccc(C(=O)CCCl)cc21.CC1(C)CC(=O)Nc2ccccc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.49
HDAC4 P56524 6/20 0.49
HDAC1 Q13547 6/20 0.49
HDAC2 Q92769 6/20 0.49
HDAC8 Q9BY41 6/20 0.49
HDAC6 Q9UBN7 6/20 0.49
HDAC9 Q9UKV0 6/20 0.49
RARB P10826 1/20 0.44
RARG P13631 1/20 0.44
HDAC7 Q8WUI4 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
HTR1A P08908 1/20 0.39
DRD2 P14416 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR7 P34969 1/20 0.39
DRD3 P35462 1/20 0.39
HTR2B P41595 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6218261 0.94 HDAC6 (0.54) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL6450714 0.84 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL11470235 0.80 HDAC6 (0.54) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL12467513 0.79 HDAC6 (0.53) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL377990 0.76 PDK2 (0.52) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL1764545 0.76 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL9376151 0.76 RARB (0.61) HDAC3HDAC4HDAC1HDAC2HDAC8
Hydrochloric Acid SCHEMBL30293229 0.75 PDK2 (0.50) HDAC3HDAC4HDAC1HDAC2HDAC8
SCHEMBL507553 0.75 PGR (0.48)
SCHEMBL6225349 0.74 EPHX2 (0.57) HDAC3HTR1ADRD2HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1546143-A1 HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA Warner-Lambert Company LLC (US) 2005-06-29 EP disclosed
WO-2004026864-A1 HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA WARNER-LAMBERT COMPANY LLC (US) 2004-04-01 WO disclosed