Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1540138 | 0.79 | CCNE1 (0.32) | CCNE1CDK2CDK5FFAR2 | |
| SCHEMBL933968 | 0.75 | — | — | |
| SCHEMBL1808491 | 0.74 | ERCC5 (0.36) | — | |
| SCHEMBL24166406 | 0.71 | CCNE1 (0.36) | CCNE1CDK2CDK5FFAR2 | |
| SCHEMBL6460929 | 0.71 | — | — | |
| SCHEMBL6454534 | 0.71 | — | — | |
| SCHEMBL17065252 | 0.68 | — | — | |
| SCHEMBL16268178 | 0.68 | CCNE1 (0.33) | CCNE1CDK2CDK5 | |
| SCHEMBL16267820 | 0.65 | CCNE1 (0.40) | CCNE1CDK2CDK5 | |
| SCHEMBL6348870 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-A2 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004087699-A2 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-10-14 | — | — | WO | disclosed |