Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644451 | 0.77 | KMT2A (0.55) | KMT2ACCR2PPARGKDM4EHPGD | |
| SCHEMBL26036832 | 0.73 | KMT2A (0.43) | KMT2ACCR2PPARGKDM4EHPGD | |
| SCHEMBL23809532 | 0.71 | KMT2A (0.43) | KMT2ACCR2PPARGKDM4EHPGD | |
| SCHEMBL26581211 | 0.71 | HPGD (0.51) | KMT2AKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL23809386 | 0.70 | PPARG (0.41) | KMT2ACCR2PPARGKDM4EHPGD | |
| SCHEMBL26581299 | 0.70 | KDM4E (0.48) | KMT2ACCR2KDM4EHPGDALDH1A1 | |
| SCHEMBL26581463 | 0.70 | KMT2A (0.43) | KMT2ACCR2PPARGKDM4EHPGD | |
| SCHEMBL699964 | 0.69 | CCR2 (0.65) | KMT2ACCR2KDM4EHPGDALDH1A1 | |
| SCHEMBL23809099 | 0.68 | ALDH1A1 (0.47) | KMT2ACCR2KDM4EHPGDALDH1A1 | |
| SCHEMBL23809122 | 0.68 | KMT2A (0.41) | KMT2ACCR2PPARGKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108630-A1 | Hedgehog Pathway Antagonists and Methods of Use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| US-8119640-B2 | Hedgehog pathway antagonists methods of use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110015201-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015201-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE | SHH, GLI1, SMO | KMT2A 1244/4885CCR2 4420/4885PPARG 1652/4885 |
| US-20120108630-A1 | Hedgehog Pathway Antagonists and Methods of Use | SHH, GLI1, SMO | KMT2A 1244/4885CCR2 4420/4885PPARG 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.