SCHEMBL645663

SCHEMBL645663

C[CH]N1CCC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4434 0.92
SCHEMBL5553 0.89
SCHEMBL2250645 0.89 CA1 (0.32)
SCHEMBL1447597 0.89
SCHEMBL608110 0.84
SCHEMBL3431740 0.72
SCHEMBL357819 0.72 RAB9A (0.34)
SCHEMBL213233 0.72
SCHEMBL55869 0.69
SCHEMBL356320 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024068520-A1 3-(HETERO)ARYL-5-CHLORODIFLUOROMETHYL-1,2,4-OXADIAZOLE AS FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 2024-04-04 WO claimed
WO-2024022481-A1 PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF 苏中药业集团股份有限公司 2024-02-01 WO claimed
US-11186583-B2 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2021-11-30 US claimed
CN-113620944-A Novel RET inhibitors, pharmaceutical compositions thereof and uses thereof 广东东阳光药业有限公司 2021-11-09 CN claimed
EP-3749670-B1 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA UNIV PALACKEHO (CZ) 2021-10-06 EP claimed
US-20210206760-A1 PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND AND USE THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2021-07-08 US claimed
EP-3798219-A1 PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND AND USE THEREOF Sunshine Lake Pharma Co., Ltd. (CN) 2021-03-31 EP claimed
EP-3749670-A1 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA Univerzita Palackeho v Olomouci (CZ) 2020-12-16 EP claimed
US-20200361943-A1 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2020-11-19 US claimed
WO-2019149295-A1 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2019-08-08 WO claimed
US-20050234037-A1 Compounds, compositions, and methods CYTOKINETICS, INC. 2005-10-20 US claimed
US-20050197327-A1 Compounds, compositions, and methods CYTOKINETICS, INCORPORATED 2005-09-08 US claimed
US-20050165089-A1 Compounds, compositions and methods CYTOKINETICS, INCORPORATED 2005-07-28 US claimed
WO-2005061460-A1 COMPOUNDS, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2005-07-07 WO claimed
WO-2005041888-A2 PYRIMIDIN-4-ONE COMPOUNDS, COMPOSITIONS AND METHODS CYTOKINETICS, INC. (US) 2005-05-12 WO claimed
WO-2005042697-A2 COMPOUNDS, COMPOSITIONS AND METHODS CYTOKINETICS, INC. (US) 2005-05-12 WO claimed
US-20050038016-A1 Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists ROCHE PALO ALTO LLC 2005-02-17 US claimed
WO-2004064741-A2 COMPOUNDS, COMPOSITIONS, AND METHODS CYTOKINETICS INC. (US) 2004-08-05 WO claimed
US-5567726-A SELECTIVE AGONISTS OF 5-HYDROXYTRYPTAMINE-LIKE RECEPTORS; USEFUL IN TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS MERCK, SHARP & DOHME LTD. (GB) 1996-10-22 US claimed
EP-0473387-A2 Anti-fungal triazole derivatives, their preparation and uses Sankyo Company Limited (JP) 1992-03-04 EP claimed