Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 10/20 | 0.47 |
| ▸ | HTR2B | P41595 | 6/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875844 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6875836 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6456690 | 0.82 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6456977 | 0.81 | MCHR1 (0.49) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6875998 | 0.76 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6875990 | 0.76 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6874488 | 0.76 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6874493 | 0.76 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6464429 | 0.75 | TSHR (0.50) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6877606 | 0.75 | TSHR (0.50) | MCHR1ADRA2AHTR2BADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | MCHR1 2/4885ADRA2A 117/4885HTR2B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.