Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.48 |
| ▸ | HTR2B | P41595 | 6/20 | 0.48 |
| ▸ | HRH1 | P35367 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875836 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6464429 | 0.85 | TSHR (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877606 | 0.85 | TSHR (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6879245 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6879241 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Trifluoroacetic Acid SCHEMBL6458250 | 0.84 | MCHR1 (0.47) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875990 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875998 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875146 | 0.84 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875152 | 0.84 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |