Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 8/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK14 | O94921 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457061 | 0.85 | KDM4E (0.48) | MCHR1KDM4ELMNASMN1; SMN2CCNK | |
| SCHEMBL6462481 | 0.83 | KDM4E (0.50) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6460870 | 0.83 | KDM4E (0.52) | MCHR1KDM4ELMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6459347 | 0.83 | SLC6A5 (0.51) | MCHR1KDM4ELMNASMN1; SMN2RAB9A | |
| Trifluoroacetic Acid SCHEMBL6927191 | 0.83 | SLC6A5 (0.51) | MCHR1KDM4ELMNASMN1; SMN2RAB9A | |
| SCHEMBL6464250 | 0.81 | LMNA (0.50) | MCHR1KDM4ELMNASMN1; SMN2CCNK | |
| SCHEMBL6460110 | 0.77 | KDM4E (0.49) | MCHR1KDM4ELMNASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6876795 | 0.75 | KDM4E (0.50) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6463555 | 0.74 | MEN1 (0.42) | MCHR1KDM4ELMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6930917 | 0.73 | MCHR1 (0.51) | MCHR1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | MCHR1 2/4885KDM4E 1190/4885LMNA 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.