Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 11/20 | 0.73 |
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 0.70 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 20/20 | 0.78 |
| ▸ | HTR2B | P41595 | 9/20 | 0.73 |
| ▸ | HRH1 | P35367 | 8/20 | 0.73 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460514 | 1.00 | MCHR1 (0.78) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458772 | 0.96 | MCHR1 (0.84) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458764 | 0.96 | MCHR1 (0.84) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6455999 | 0.95 | MCHR1 (0.82) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6455990 | 0.95 | MCHR1 (0.82) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6462200 | 0.89 | MCHR1 (0.84) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6462205 | 0.89 | MCHR1 (0.84) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6466371 | 0.88 | MCHR1 (0.82) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6463368 | 0.88 | MCHR1 (0.82) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6456006 | 0.88 | MCHR1 (0.70) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | ADRA2A 117/4885ADRA1A 209/4885HTR1A 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.