SCHEMBL6460149

SCHEMBL6460149

COc1c(F)cc(-c2ccc([C@@H]3CC[C@@H]4CC(C)CC[C@@H]4C3)cc2)cc1F

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 5/20 0.35
CNR2 P34972 5/20 0.35
KDM1A O60341 2/20 0.33
SLC6A3 Q01959 1/20 0.33
ESR2 Q92731 1/20 0.33
FFAR4 Q5NUL3 1/20 0.31
PDGFRB P09619 1/20 0.31
PDGFRA P16234 1/20 0.31
NAAA Q02083 1/20 0.31
TGFBR1 P36897 1/20 0.30
ACVR1 Q04771 1/20 0.30
IDH1 O75874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6460151 1.00 CNR1 (0.35) CNR1CNR2KDM1ASLC6A3ESR2
SCHEMBL6453467 0.89 L3MBTL1 (0.32) SLC6A3ESR2IDH1
SCHEMBL6453465 0.89 L3MBTL1 (0.32) SLC6A3ESR2IDH1
SCHEMBL6465196 0.87 KDM1A (0.45) KDM1APDGFRBPDGFRANAAA
SCHEMBL6465199 0.87 KDM1A (0.45) KDM1APDGFRBPDGFRANAAA
SCHEMBL6453783 0.87 ESR2 (0.36) KDM1ASLC6A3ESR2
SCHEMBL6453779 0.87 ESR2 (0.36) KDM1ASLC6A3ESR2
SCHEMBL6458293 0.86 ESR2 (0.31) ESR2
SCHEMBL6451210 0.86 FASN (0.35) KDM1A
SCHEMBL6458296 0.86 ESR2 (0.31) ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6913797-B1 Decahydronaphthalene derivative DAINIPPON INK AND CHEMICALS, INC. (JP) 2005-07-05 US disclosed
EP-1108700-A1 DECAHYDRONAPHTHALENE DERIVATIVE DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-06-20 EP disclosed