SCHEMBL6465196

SCHEMBL6465196

COc1ccc(-c2ccc([C@@H]3CC[C@@H]4CC(C)CC[C@@H]4C3)cc2)cc1F

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.45
NAAA Q02083 11/20 0.42
CYP17A1 P05093 1/20 0.41
TDP2 O95551 1/20 0.40
PTGS2 P35354 3/20 0.38
PDGFRB P09619 1/20 0.38
PDGFRA P16234 1/20 0.38
PTGS1 P23219 1/20 0.38
ERN1 O75460 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6465199 1.00 KDM1A (0.45) KDM1ANAAACYP17A1TDP2PTGS2
SCHEMBL6463710 0.88 NAAA (0.39) KDM1ANAAA
SCHEMBL6455560 0.88 KDM1A (0.44) KDM1ANAAATDP2PTGS2PTGS1
SCHEMBL6455561 0.88 KDM1A (0.44) KDM1ANAAATDP2PTGS2PTGS1
SCHEMBL6455023 0.88 GRM2 (0.35) KDM1ANAAACYP17A1TDP2
SCHEMBL6463716 0.88 NAAA (0.39) KDM1ANAAA
SCHEMBL6455027 0.88 GRM2 (0.35) KDM1ANAAACYP17A1TDP2
SCHEMBL6464726 0.88 KDM1A (0.43) KDM1ANAAACYP17A1TDP2PTGS2
SCHEMBL6464722 0.88 KDM1A (0.43) KDM1ANAAACYP17A1TDP2PTGS2
SCHEMBL6460149 0.87 CNR1 (0.35) KDM1ANAAAPDGFRBPDGFRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6913797-B1 Decahydronaphthalene derivative DAINIPPON INK AND CHEMICALS, INC. (JP) 2005-07-05 US disclosed
EP-1108700-A1 DECAHYDRONAPHTHALENE DERIVATIVE DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-06-20 EP disclosed