Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.43 |
| ▸ | HRH1 | P35367 | 6/20 | 0.43 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460796 | 1.00 | JAK2 (0.45) | JAK2JAK1MCHR1ADRA2AHRH1 | |
| SCHEMBL6458263 | 0.85 | JAK1 (0.43) | JAK2JAK1KDM1AMAOBAURKB | |
| SCHEMBL6458275 | 0.85 | JAK1 (0.43) | JAK2JAK1KDM1AMAOBAURKB | |
| SCHEMBL6876294 | 0.83 | MCHR1 (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6876287 | 0.83 | MCHR1 (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6455641 | 0.82 | MCHR1 (0.48) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464308 | 0.82 | CNR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6464302 | 0.82 | CNR1 (0.62) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL16091554 | 0.81 | KDM1A (0.50) | JAK2JAK1KDM1AMAOBCKS1B | |
| SCHEMBL6867773 | 0.80 | ALDH1A1 (0.54) | JAK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | JAK2 333/4885JAK1 815/4885MCHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.