Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.68 |
| ▸ | HRH2 | P25021 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | HRH1 | P35367 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethybenztropine SCHEMBL29690837 | 0.85 | DRD2 (0.72) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Ethybenztropine SCHEMBL250681 | 0.85 | DRD2 (0.72) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Ethybenztropine SCHEMBL250682 | 0.85 | DRD2 (0.72) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Ethybenztropine SCHEMBL1649586 | 0.85 | DRD2 (0.72) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| SCHEMBL466916 | 0.85 | DRD2 (0.68) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| SCHEMBL11395839 | 0.82 | SLC6A3 (0.76) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| SCHEMBL11399038 | 0.81 | DRD2 (0.62) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Benztropine SCHEMBL35388 | 0.81 | DRD2 (1.00) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Benztropine SCHEMBL5960155 | 0.81 | DRD2 (1.00) | DRD2DRD3SLC6A2CHRM2CHRM4 | |
| Benztropine SCHEMBL8659140 | 0.81 | DRD2 (1.00) | DRD2DRD3SLC6A2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494664-A2 | COMBINATIONS OF COX-2 INHIBITORS AND OTHER AGENTS FOR THE TREATMENT OF PARKINSON'S DISEASE | Pharmacia Corporation (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003088958-A2 | COMBINATIONS OF COX-2 INHIBITORS AND OTHER AGENTS FOR THE TREATMENT OF PARKINSON’S DISEASE | PHARMACIA CORPORATION (US) | 2003-10-30 | — | — | WO | disclosed |