Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | LIG1 | P18858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11558761 | 0.85 | MAOA (0.48) | KDM1A | |
| SCHEMBL24816477 | 0.85 | MAOA (0.48) | KDM1A | |
| SCHEMBL6460757 | 0.80 | KCNH2 (0.41) | IDO1HSD11B1SMN1; SMN2 | |
| SCHEMBL5774057 | 0.74 | KDM1A (0.40) | KDM1ARCOR1MMEHTR2ATAAR1 | |
| SCHEMBL12813767 | 0.73 | MAOA (0.50) | KDM1ARCOR1MMEHTR2ATAAR1 | |
| SCHEMBL16041470 | 0.70 | MAOA (0.61) | KDM1ARCOR1HTR2ATAAR1IDO1 | |
| SCHEMBL24816872 | 0.70 | HPGD (0.38) | TAAR1HPGDSMN1; SMN2 | |
| SCHEMBL4118095 | 0.69 | GRIN1 (0.33) | — | |
| SCHEMBL23595819 | 0.69 | GRIN1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL22615595 | 0.69 | MAOA (0.59) | KDM1ARCOR1HTR2ATAAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974815-B2 | Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20040116467-A1 | Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents | CEREP SA (FR) | 2004-06-17 | — | — | US | disclosed |
| WO-2004032861-A2 | HEXAHYDRO-BENZIMIDAZOLONE COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-22 | — | — | WO | disclosed |