Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.46 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463409 | 1.00 | ADRA2A (0.46) | ADRA2AMCHR1NPY5RDCPSGPR6 | |
| Hydrochloric Acid SCHEMBL6464588 | 0.99 | ADRA2A (0.46) | ADRA2AMCHR1NPY5RDCPSGPR6 | |
| SCHEMBL6828839 | 0.89 | ADRA2A (0.54) | ADRA2AMCHR1NPY5RDCPSGPR6 | |
| SCHEMBL6463643 | 0.89 | ADRA2A (0.54) | ADRA2AMCHR1NPY5RDCPSGPR6 | |
| Hydrochloric Acid SCHEMBL6456272 | 0.88 | ADRA2A (0.53) | ADRA2AMCHR1NPY5RDCPSGPR6 | |
| SCHEMBL6466799 | 0.82 | APP (0.35) | ADRA2AMCHR1NPY5RGPR6ELANE | |
| SCHEMBL6457077 | 0.81 | SSTR5 (0.35) | ADRA2AMCHR1NPY5RGPR6ELANE | |
| Hydrochloric Acid SCHEMBL6614692 | 0.79 | MCHR1 (0.51) | ADRA2AMCHR1NPY5RDCPSPRKCQ | |
| SCHEMBL6462207 | 0.78 | CD274 (0.41) | PRKCQELANE | |
| SCHEMBL13793992 | 0.74 | NPY5R (0.63) | ADRA2AMCHR1NPY5RPRKCQEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | claimed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | claimed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | claimed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | ADRA2A 117/4885MCHR1 2/4885NPY5R 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.