Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | ESR1 | P03372 | 6/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | PGR | P06401 | 2/20 | 0.77 |
| ▸ | AR | P10275 | 2/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.77 |
| ▸ | ATM | Q13315 | 2/20 | 0.77 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.77 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.77 |
| ▸ | STS | P08842 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estradiol Methyl Ether SCHEMBL12593628 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL14499084 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL8998255 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL15263441 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL547265 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL23645792 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL18686406 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL9558220 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| Estradiol Methyl Ether SCHEMBL4750578 | 1.00 | HSD17B10 (1.00) | HSD17B10LMNAESR1SMN1; SMN2PGR | |
| SCHEMBL980768 | 0.92 | LMNA (0.85) | HSD17B10LMNAESR1SMN1; SMN2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |
| EP-1163259-A1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | Akzo Nobel N.V. (NL) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000053619-A1 | 14.BETA., 17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL N.V. (NL) | 2000-09-14 | — | — | WO | disclosed |