Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166274 | 0.90 | NPC1 (0.43) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL475621 | 0.89 | NPC1 (0.39) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL3346033 | 0.88 | NPC1 (0.42) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL3512727 | 0.86 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL3510505 | 0.86 | RAB9A (0.45) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL168243 | 0.84 | MEN1 (0.51) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL2710613 | 0.82 | NPC1 (0.38) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL475620 | 0.81 | NPC1 (0.38) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL2711948 | 0.79 | NPC1 (0.48) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL3648036 | 0.79 | RAB9A (0.42) | NPC1RAB9AALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |