SCHEMBL6465402

SCHEMBL6465402

COc1ccc(NC(=O)NS(C)(=O)=O)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 3/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
HSP90AA1 P07900 1/20 0.51
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
PLK1 P53350 1/20 0.46
KDR P35968 2/20 0.45
SLC2A1 P11166 1/20 0.45
KEAP1 Q14145 1/20 0.45
NFE2L2 Q16236 1/20 0.45
MAPK14 Q16539 1/20 0.43
FABP4 P15090 1/20 0.43
HTR2C P28335 1/20 0.43
HTR2B P41595 1/20 0.43
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6467306 0.81 NLRP3 (0.49) KMT2AKDM4EALDH1A1KEAP1MAPK14
SCHEMBL6465344 0.79 EP300 (0.43) KMT2A
SCHEMBL24101640 0.79 EP300 (0.60) CDC25BMEN1KMT2AKDM4EALDH1A1
SCHEMBL8027669 0.79 RXFP1 (0.60) CDC25BMEN1KMT2AHSP90AA1KDM4E
SCHEMBL6880369 0.79 CDC25B (0.59) CDC25BMEN1KMT2AHSP90AA1KDM4E
SCHEMBL18415502 0.76 CDC25B (0.56) CDC25BMEN1KMT2AHSP90AA1KDM4E
SCHEMBL6537093 0.76 NLRP3 (0.61) MEN1KMT2AKDM4EALDH1A1KEAP1
SCHEMBL16139183 0.76 MAPK14 (0.76) MAPK14
SCHEMBL7738209 0.75 IDO1 (0.67) CDC25BMEN1KMT2AHSP90AA1KDM4E
SCHEMBL18778762 0.74 CDC25B (0.54) CDC25BMEN1KMT2AHSP90AA1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0615859-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-06-03 EP claimed
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US claimed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP claimed
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
US-6740465-B2 MULTILAYER; TRANSPARENT SUPPORT; HEAT SENSITIVE ELEMENT AND RELEASE AGENT SIPIX IMAGING, INC. 2004-05-25 US disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
EP-1289768-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES Sipix Imaging, Inc. (US) 2003-03-12 EP disclosed
CN-1386095-A Imaging media containing heat developable photosensitive microcapsule SIPIX IMAGING INC (US) 2002-12-18 CN disclosed
US-20020155372-A1 Imaging media containing heat developable photosensitive microcapsules SIPIX IMAGING, INC. 2002-10-24 US disclosed
WO-2001092024-A2 IMAGING MEDIA CONTAINING HEAT DEVELOPABLE PHOTOSENSITIVE MICROCAPSULES SIPIX IMAGING, INC. (US) 2001-12-06 WO disclosed
EP-0615859-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-06-03 EP disclosed
US-5449657-A Sulfonyl (thio)ureas NEW OJI PAPER CO., LTD. (JP) 1995-09-12 US disclosed
EP-0615859-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-09-21 EP disclosed