SCHEMBL6467306

SCHEMBL6467306

CS(=O)(=O)NC(=O)Nc1cccc2c(NC(=O)NS(C)(=O)=O)cccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 1/20 0.49
TRPV1 Q8NER1 2/20 0.45
KDM4E B2RXH2 4/20 0.45
MAPT P10636 1/20 0.45
KEAP1 Q14145 1/20 0.44
RAB9A P51151 2/20 0.44
EPHX1 P07099 1/20 0.44
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 3/20 0.44
POLB P06746 3/20 0.44
CYP1A2 P05177 1/20 0.43
RECQL P46063 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAPK14 Q16539 1/20 0.42
EP300 Q09472 1/20 0.42
KAT2B Q92831 1/20 0.42
KAT8 Q9H7Z6 1/20 0.42
KMT2A Q03164 1/20 0.42
GAA P10253 1/20 0.42
GSK3B P49841 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6537093 0.90 NLRP3 (0.61) NLRP3KDM4EMAPTKEAP1RAB9A
SCHEMBL6465344 0.84 EP300 (0.43) NLRP3TRPV1RAB9APOLBCYP1A2
SCHEMBL6465402 0.81 CDC25B (0.51) KDM4EMAPTKEAP1ALDH1A1MAPK14
SCHEMBL13509003 0.80 NPC1 (0.58) MAPTRAB9AHSD17B10ALDH1A1POLB
SCHEMBL13509001 0.77 CFD (0.54) KDM4EMAPTRAB9AALDH1A1POLB
SCHEMBL6243122 0.77 L3MBTL1 (0.70) NLRP3KDM4EMAPTKEAP1RAB9A
SCHEMBL8417081 0.76 NLRP3 (0.54) NLRP3KDM4ERAB9AALDH1A1KMT2A
SCHEMBL6467495 0.76 ACP1 (0.52) MAPTALDH1A1POLBSMN1; SMN2KMT2A
SCHEMBL28750618 0.75 KMT2A (0.60) KDM4EMAPTKEAP1HSD17B10ALDH1A1
SCHEMBL8756964 0.75 RAB9A (0.49) NLRP3TRPV1KDM4ERAB9AEPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed