Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 4/20 | 0.33 |
| ▸ | HMGCR | P04035 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240006 | 0.95 | HMGCR (0.35) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL8649300 | 0.83 | HMGCR (0.38) | PTPN7HMGCRRECQLTDP1 | |
| SCHEMBL12095321 | 0.76 | HMGCR (0.32) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL7554246 | 0.75 | USP2 (0.30) | HMGCRUSP2SMN1; SMN2 | |
| SCHEMBL28334123 | 0.75 | PTPN7 (0.50) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL7122689 | 0.74 | DNM1 (0.42) | PTPN7HMGCRRECQLTDP1 | |
| SCHEMBL10512238 | 0.72 | PTPN7 (0.34) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL5142033 | 0.71 | PTPN7 (0.45) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL61022 | 0.71 | HMGCR (0.37) | PTPN7HMGCRKDM4EALDH1A1HPGD | |
| SCHEMBL60205 | 0.71 | HMGCR (0.37) | PTPN7HMGCRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507528-A2 | METHODS FOR USING JNK INHIBITORS FOR TREATING OR PREVENTING DISEASE-RELATED WASTING | Signal Pharmaceuticals, Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003099221-A2 | METHODS FOR USING JNK INHIBITORS FOR TREATING OR PREVENTING DISEASE-RELATED WASTING | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |