Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.33 |
| ▸ | GHSR | Q92847 | 6/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26864272 | 0.86 | HRH3 (0.36) | KCNH2MAOB | |
| SCHEMBL26890222 | 0.82 | DRD2 (0.40) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL6464178 | 0.77 | HRH3 (0.39) | KCNH2MAOB | |
| SCHEMBL16376634 | 0.77 | KCNH2 (0.36) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL21037748 | 0.77 | KCNH2 (0.36) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL9926452 | 0.77 | KCNH2 (0.36) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL14210643 | 0.77 | KCNH2 (0.36) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL20235020 | 0.77 | DRD3 (0.37) | DRD2DRD3KCNH2CYP2D6MAOB | |
| SCHEMBL1789882 | 0.77 | KCNH2 (0.39) | DRD2DRD3KCNH2CCR2CYP2D6 | |
| SCHEMBL12209133 | 0.76 | NCF1 (0.39) | DRD2DRD3KCNH2CCR2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | claimed |