Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986546 | 0.87 | NOTUM (0.39) | NOTUML3MBTL1 | |
| SCHEMBL5363605 | 0.83 | NOTUM (0.34) | NOTUML3MBTL1 | |
| SCHEMBL6464955 | 0.83 | NOTUM (0.36) | NOTUML3MBTL1 | |
| SCHEMBL8442070 | 0.83 | NOTUM (0.34) | NOTUML3MBTL1 | |
| SCHEMBL7969705 | 0.80 | NOTUM (0.41) | NOTUML3MBTL1 | |
| SCHEMBL10813663 | 0.79 | CYP19A1 (0.36) | NOTUML3MBTL1 | |
| SCHEMBL20309609 | 0.79 | NOTUM (0.40) | NOTUML3MBTL1 | |
| SCHEMBL8442514 | 0.76 | KDM1A (0.36) | NOTUML3MBTL1 | |
| SCHEMBL5041170 | 0.75 | MIF (0.42) | — | |
| SCHEMBL5357402 | 0.75 | P2RX7 (0.40) | NOTUML3MBTL1KDM4EMAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110204550-B | Bicyclic compounds as Autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors | 豪夫迈·罗氏有限公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-107922412-B | Bicyclic compounds as ATX inhibitors | 豪夫迈·罗氏有限公司 | 2021-02-23 | — | — | CN | disclosed |
| CN-106103446-B | Bicyclic compounds as Autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors | 豪夫迈·罗氏有限公司 | 2019-07-30 | — | — | CN | disclosed |
| EP-3353176-A1 | BICYCLIC COMPOUNDS AS ATX INHIBITORS | H. Hoffnabb-La Roche Ag (CH) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017050792-A1 | BICYCLIC COMPOUNDS AS ATX INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-03-30 | — | — | WO | disclosed |
| EP-3122750-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| CN-106103446-A | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors | 豪夫迈·罗氏有限公司 | 2016-11-09 | — | — | CN | disclosed |
| WO-2015144605-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-01 | — | — | WO | disclosed |
| EP-2776435-A1 | ANTICANCER PYRIDOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | Astex Therapeutics Limited (GB) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013061080-A1 | ANTICANCER PYRIDOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |
| EP-0594263-B1 | INTERMEDIATES FOR THE PREPARATION OF THIOALKYLTHIO CEPHALOSPORIN DERIVATIVES | SHIONOGI & CO (JP) | 1999-06-09 | — | — | EP | disclosed |
| CN-1034504-C | Thioalkylthio cephalosporin derivatives | SHIONOGI & CO (JP) | 1997-04-09 | — | — | CN | disclosed |
| US-5352792-A | Bactericides | SHIONOGI & CO., LTD. (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0467647-B1 | Thioalkylthio cephalosporin derivatives | SHIONOGI & CO (JP) | 1994-08-17 | — | — | EP | disclosed |
| EP-0594263-A1 | Thioalkylthio cephalosporin derivatives and intermediates | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| US-5214037-A | Antibiotic, bactericide | SHIONOGI & CO., LTD. (JP) | 1993-05-25 | — | — | US | disclosed |
| EP-0467647-A2 | Thioalkylthio cephalosporin derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-01-22 | — | — | EP | disclosed |
| EP-0091130-B1 | CEPHALOSPORIN DERIVATIVES, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | DAIICHI SEIYAKU CO., LTD. (JP) | 1987-04-08 | — | — | EP | disclosed |
| US-4603198-A | Cephalosporin derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0091130-A2 | Cephalosporin derivatives, process for preparing and pharmaceutical compositions containing said compounds | DAIICHI SEIYAKU CO., LTD. (JP) | 1983-10-12 | — | — | EP | disclosed |