Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.36 |
| ▸ | DDX3X | O00571 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465900 | 0.87 | NOTUM (0.53) | NOTUML3MBTL1 | |
| SCHEMBL5363605 | 0.80 | NOTUM (0.34) | NOTUML3MBTL1CYP19A1MAOA | |
| SCHEMBL6464955 | 0.80 | NOTUM (0.36) | NOTUML3MBTL1CYP19A1MAOA | |
| SCHEMBL8442070 | 0.80 | NOTUM (0.34) | NOTUML3MBTL1CYP19A1MAOA | |
| SCHEMBL5041170 | 0.79 | MIF (0.42) | CYP19A1 | |
| SCHEMBL7969705 | 0.77 | NOTUM (0.41) | NOTUML3MBTL1CYP19A1KMT2AMAOA | |
| SCHEMBL10813663 | 0.76 | CYP19A1 (0.36) | NOTUML3MBTL1CYP19A1CA1CA2 | |
| SCHEMBL20309609 | 0.76 | NOTUM (0.40) | NOTUML3MBTL1CYP19A1 | |
| SCHEMBL7969475 | 0.75 | CYP4F2 (0.39) | TDP1CA1CA2CA9 | |
| SCHEMBL14212094 | 0.74 | NOTUM (0.41) | NOTUMCYP19A1DDX3XCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |