SCHEMBL6466427

SCHEMBL6466427

Cc1cc2c(cc1Cl)oc1c(Cl)c(Cl)c(Cl)cc12

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AHR P35869 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29349569 0.87 AHR (1.00) AHR
SCHEMBL2281485 0.87 AHR (1.00) AHR
SCHEMBL6466778 0.81 AHR (0.73) AHR
SCHEMBL6465632 0.77 AHR (0.74) AHR
SCHEMBL8952247 0.77 AHR (0.73) AHR
SCHEMBL29568936 0.76 AHR (1.00) AHR
SCHEMBL2278973 0.76 AHR (1.00) AHR
SCHEMBL2286823 0.73 AHR (1.00) AHR
SCHEMBL6466410 0.73 AHR (0.70) AHR
SCHEMBL6468484 0.73 AHR (0.67) AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050143450-A1 Alkyl PCDF as a treatment for prostate cancer TEXAS A&M UNIVERSITY SYSTEM (US) 2005-06-30 US claimed
EP-1140047-B1 ENDOCRINE THERAPY FOR BREAST CANCER: COMBINED TREATMENT WITH TAMOXIFEN PLUS ALKYL PCDFS TEXAS A & M UNIV SYS (US) 2003-10-29 EP claimed
EP-1608306-A2 ALKYL-SUBSTITUTED PCDF AS A TREATMENT FOR PROSTATE CANCER THE TEXAS A & M UNIVERSITY SYSTEM (US) 2005-12-28 EP disclosed
US-20050143450-A1 Alkyl PCDF as a treatment for prostate cancer TEXAS A&M UNIVERSITY SYSTEM (US) 2005-06-30 US disclosed
WO-2005032452-A2 ALKYL-SUBSTITUTED PCDF AS A TREATMENT FOR PROSTATE CANCER TEXAS A & M UNIVERSITY SYSTEM (US) 2005-04-14 WO disclosed
EP-1140047-B1 ENDOCRINE THERAPY FOR BREAST CANCER: COMBINED TREATMENT WITH TAMOXIFEN PLUS ALKYL PCDFS TEXAS A & M UNIV SYS (US) 2003-10-29 EP disclosed
US-5516790-A Synthesis and application of alkyl-substituted dibenzofurans as antitumorigenic agents TEXAS A&M UNIVERSITY SYSTEM TECHNOLOGY LICENSING OFFICE (US) 1996-05-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050143450-A1 Alkyl PCDF as a treatment for prostate cancer KLK3, ACP3, AR AHR 379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.