Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 10/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462853 | 0.88 | LMNA (0.62) | LMNAHSD17B10ESR1ESR2MAPT | |
| SCHEMBL18935677 | 0.84 | LMNA (0.54) | LMNAHSD17B10ESR1ESR2CYP19A1 | |
| SCHEMBL18886672 | 0.80 | LMNA (0.53) | LMNAHSD17B10ESR1ESR2CYP19A1 | |
| SCHEMBL6462167 | 0.79 | LMNA (0.74) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL6468136 | 0.79 | LMNA (0.74) | LMNAHSD17B10ESR1MAPTHSD17B1 | |
| SCHEMBL6468149 | 0.78 | LMNA (0.51) | LMNAHSD17B10ESR1CYP19A1MAPT | |
| SCHEMBL6465770 | 0.78 | LMNA (0.64) | LMNAHSD17B10ESR1ESR2CYP19A1 | |
| SCHEMBL6468077 | 0.78 | LMNA (0.64) | LMNAHSD17B10ESR1ESR2CYP19A1 | |
| SCHEMBL11101794 | 0.78 | LMNA (0.64) | LMNAHSD17B10ESR1ESR2CYP19A1 | |
| SCHEMBL13244691 | 0.76 | ESR1 (0.49) | LMNAHSD17B10ESR1ESR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |