Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | ESR1 | P03372 | 13/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466469 | 0.88 | LMNA (0.50) | LMNAHSD17B10ESR1ESR2PGR | |
| SCHEMBL10523747 | 0.87 | HSD17B10 (0.67) | LMNAHSD17B10ESR1ESR2ABCC1 | |
| SCHEMBL10522508 | 0.87 | HSD17B10 (0.67) | LMNAHSD17B10ESR1ESR2ABCC1 | |
| SCHEMBL11096095 | 0.86 | LMNA (0.66) | LMNAHSD17B10ESR1ESR2ABCC1 | |
| SCHEMBL17525985 | 0.86 | ESR1 (0.76) | LMNAHSD17B10ESR1ESR2PGR | |
| SCHEMBL11094746 | 0.86 | ESR1 (0.76) | LMNAHSD17B10ESR1ESR2PGR | |
| SCHEMBL9519936 | 0.82 | ESR1 (0.59) | LMNAHSD17B10ESR1ESR2ABCC1 | |
| SCHEMBL18935677 | 0.81 | LMNA (0.54) | LMNAHSD17B10ESR1ESR2ABCC1 | |
| SCHEMBL6860703 | 0.81 | ESR1 (0.54) | LMNAHSD17B10ESR1ESR2AR | |
| SCHEMBL6468149 | 0.80 | LMNA (0.51) | LMNAHSD17B10ESR1ABCC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881728-B1 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens | AKZO NOBEL N.V. (NL) | 2005-04-19 | — | — | US | disclosed |
| EP-1163259-B1 | 14.BETA.,17-ALPHA-HYDROXYMETHYLANDROSTANE DERIVATIVES AS ANDROGENS | AKZO NOBEL NV (NL) | 2002-11-20 | — | — | EP | disclosed |