Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 2/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467781 | 0.92 | SMN1; SMN2 (0.36) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL2725564 | 0.90 | SMN1; SMN2 (0.34) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL2725565 | 0.90 | SMN1; SMN2 (0.34) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL6468229 | 0.87 | BACE1 (0.37) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL10290109 | 0.87 | — | — | |
| SCHEMBL2726988 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2TRPV1HCRTR1HCRTR2CPT2 | |
| SCHEMBL6468770 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL10289972 | 0.84 | USP30 (0.37) | SMN1; SMN2ACETRPV1HCRTR1HCRTR2 | |
| SCHEMBL2729431 | 0.83 | CPT1A (0.40) | SMN1; SMN2ACETRPV1KLK5CPT2 | |
| SCHEMBL10290121 | 0.82 | SCD5 (0.36) | ACEHCRTR1HCRTR2KLK5CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |