Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 9/20 | 0.46 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087646 | 0.94 | LTA4H (0.55) | AS3MTSRD5A2LTA4HKDM1ARCOR1 | |
| SCHEMBL6087655 | 0.94 | LTA4H (0.55) | AS3MTSRD5A2LTA4HKDM1ARCOR1 | |
| SCHEMBL6087307 | 0.82 | SRD5A2 (0.48) | AS3MTSRD5A2LTA4HKDM1ARCOR1 | |
| SCHEMBL6087534 | 0.77 | SRD5A2 (0.64) | AS3MTSRD5A2MEN1NPC1RAB9A | |
| SCHEMBL6087478 | 0.77 | SRD5A2 (0.81) | SRD5A2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6087315 | 0.74 | SRD5A2 (0.48) | SRD5A2LTA4HMEN1NPC1RAB9A | |
| SCHEMBL6087316 | 0.74 | SRD5A2 (0.48) | SRD5A2LTA4HMEN1NPC1RAB9A | |
| SCHEMBL5640259 | 0.74 | MAOB (0.48) | AS3MTLTA4HMAOB | |
| SCHEMBL6087410 | 0.73 | SRD5A2 (0.58) | SRD5A2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6087661 | 0.73 | CFD (0.60) | AS3MTSRD5A2LTA4HSIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |