Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65686 | 0.82 | PDK1 (0.38) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL9384838 | 0.79 | ABCB1 (0.40) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL65232 | 0.79 | TMEM97 (0.37) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL18740344 | 0.79 | CYP2C19 (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL15341340 | 0.78 | PDK1 (0.45) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL8699830 | 0.78 | POLB (0.49) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL13340947 | 0.78 | POLB (0.49) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL1058641 | 0.78 | POLB (0.49) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL1058639 | 0.78 | POLB (0.49) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL5765731 | 0.77 | ELANE (0.40) | POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |