Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 4/20 | 0.31 |
| ▸ | CPT2 | P23786 | 3/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728147 | 0.95 | SMN1; SMN2 (0.34) | SMN1; SMN2NOS1NOS2NAPEPLDTRPV1 | |
| SCHEMBL2727853 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL6466775 | 0.90 | ACACB (0.40) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL6468061 | 0.90 | CPT1A (0.39) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL2726650 | 0.89 | NAPEPLD (0.34) | NOS1NOS2NAPEPLDTRPV1ROCK2 | |
| SCHEMBL2726646 | 0.89 | NAPEPLD (0.34) | NOS1NOS2NAPEPLDTRPV1ROCK2 | |
| SCHEMBL6467607 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL6466318 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL6466750 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2TRPV1ACACBACACAKLK5 | |
| SCHEMBL6467618 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2TRPV1ACACBACACAKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |