Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.44 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467998 | 0.92 | RAF1 (0.43) | RAF1FGFR2RETEGFRMAP2K1 | |
| Trifluoroacetic Acid SCHEMBL6469150 | 0.89 | RET (0.42) | RAF1RETEGFRKDRAVPR1B | |
| Trifluoroacetic Acid SCHEMBL6471240 | 0.88 | RET (0.43) | RAF1RETEGFRSRCKDR | |
| Trifluoroacetic Acid SCHEMBL6469209 | 0.88 | RET (0.43) | RETEGFRKDRAVPR1BPDGFRB | |
| Trifluoroacetic Acid SCHEMBL6469939 | 0.88 | AVPR1B (0.43) | RAF1SIK2SIK3AVPR1B | |
| Trifluoroacetic Acid SCHEMBL6469649 | 0.88 | RAF1 (0.39) | RAF1RETAVPR1B | |
| Trifluoroacetic Acid SCHEMBL6470128 | 0.87 | PDK1 (0.41) | RAF1RETAVPR1B | |
| Trifluoroacetic Acid SCHEMBL6468017 | 0.85 | HSD17B10 (0.40) | RAF1RETKDRAVPR1B | |
| Trifluoroacetic Acid SCHEMBL6468678 | 0.85 | HRH3 (0.46) | RETAVPR1B | |
| Trifluoroacetic Acid SCHEMBL6469205 | 0.84 | KDM4E (0.36) | RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | claimed |
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | claimed |
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | RAF1 2421/4885FGFR2 4843/4885RET 4244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.