Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.53 |
| ▸ | MME | P08473 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468863 | 1.00 | ACE (0.53) | ACEMMEALDH1A1LMNAMAPT | |
| SCHEMBL1734807 | 0.81 | ALDH1A1 (0.46) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL3045357 | 0.81 | ALDH1A1 (0.46) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL6376785 | 0.79 | TP53 (0.46) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL16481929 | 0.79 | SMN1; SMN2 (0.44) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL29851772 | 0.79 | TP53 (0.46) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL595439 | 0.77 | DPP4 (0.48) | MMEALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL595438 | 0.77 | DPP4 (0.48) | MMEALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL6860583 | 0.77 | FPR2 (0.43) | MMEALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL2739557 | 0.77 | SLC7A5 (0.48) | MMEALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058269-A2 | METHODS OF TREATING CANCER AND OTHER DISEASES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-05-03 | — | — | WO | disclosed |