Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | JUND | P17535 | 1/20 | 0.38 |
| ▸ | FOSB | P53539 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12135957 | 0.80 | KMT2A (0.47) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL20813807 | 0.74 | PDE5A (0.42) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL20867656 | 0.72 | MAPT (0.50) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL2124865 | 0.72 | KMT2A (0.49) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL2125303 | 0.72 | CYP3A4 (0.49) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL22750299 | 0.70 | CRHR1 (0.47) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL20521814 | 0.70 | CYP3A4 (0.44) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL22196185 | 0.70 | KMT2A (0.44) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL20521940 | 0.70 | KMT2A (0.44) | KMT2ASMN1; SMN2LMNAPOLBRAD52 | |
| SCHEMBL29923906 | 0.70 | CRHR1 (0.47) | KMT2ASMN1; SMN2LMNAPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | disclosed |