Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468851 | 0.88 | KMT2A (0.41) | KMT2ASIRT6P4HTMNAMPTVNN1 | |
| SCHEMBL2677914 | 0.84 | ALDH1A1 (0.44) | KMT2ASIRT6P4HTMTSHRNPC1 | |
| SCHEMBL6469024 | 0.84 | KMT2A (0.39) | KMT2ASIRT6P4HTMNAMPTVNN1 | |
| SCHEMBL6469006 | 0.82 | KMT2A (0.47) | KMT2ASIRT6P4HTMNAMPTHRH3 | |
| SCHEMBL5040340 | 0.81 | KMT2A (0.41) | KMT2ASIRT6P4HTMNAMPTVNN1 | |
| SCHEMBL8953636 | 0.80 | KMT2A (0.49) | KMT2ASIRT6P4HTMNAMPTHRH3 | |
| SCHEMBL5040582 | 0.79 | KMT2A (0.35) | KMT2ASIRT6P4HTMNAMPTVNN1 | |
| SCHEMBL6650658 | 0.79 | KMT2A (0.45) | KMT2ASIRT6P4HTMNAMPTHRH3 | |
| SCHEMBL5037523 | 0.77 | KMT2A (0.43) | KMT2ASIRT6NAMPTVNN1GRM2 | |
| SCHEMBL6470782 | 0.77 | KMT2A (0.43) | KMT2ASIRT6NAMPTVNN1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | KMT2A 2085/4885SIRT6 750/4885P4HTM 3028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.