Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469006 | 0.86 | KMT2A (0.47) | KMT2ASIRT6NNMTAPPHRH3 | |
| SCHEMBL6652918 | 0.84 | P4HTM (0.49) | KMT2ATSHRP4HTMLMNAMAPT | |
| SCHEMBL8953636 | 0.84 | KMT2A (0.49) | KMT2ASIRT6NNMTAPPHRH3 | |
| SCHEMBL6649788 | 0.80 | MAPT (0.41) | TSHRTLR8TLR7NPC1LMNA | |
| SCHEMBL6650491 | 0.80 | MAPK1 (0.56) | HRH3LCKNPC1LMNAMAPT | |
| SCHEMBL6651599 | 0.80 | PIK3CD (0.41) | APLNRP4HTMNPC1MAPTRAB9A | |
| SCHEMBL29571426 | 0.80 | MAPK1 (0.56) | HRH3LCKNPC1LMNAMAPT | |
| SCHEMBL6469092 | 0.79 | KMT2A (0.41) | KMT2ASIRT6NNMTAPPHRH3 | |
| SCHEMBL2677914 | 0.78 | ALDH1A1 (0.44) | KMT2ASIRT6TSHRP4HTMNPC1 | |
| SCHEMBL22888217 | 0.77 | KMT2A (0.54) | KMT2ASIRT6NNMTAPPHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926137-B1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6416979-B1 | MARASMIELLUS CULTURE PRODUCT; ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENTS | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6194442-B1 | ANTIINFLAMMATORY AGENT | PFIZER INC | 2001-02-27 | — | — | US | disclosed |
| US-6034107-A | RHEUMATIC DISORDERS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0926137-A1 | Picolin acid derivatives useful in the treatment of IL-1 and TNF mediated diseases | PFIZER INC. (US) | 1999-06-30 | — | — | EP | disclosed |