Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6469205 | 0.92 | KDM4E (0.36) | WHR1AURKAALDH1A1KDM4EMAPT | |
| Trifluoroacetic Acid SCHEMBL6469150 | 0.89 | RET (0.42) | WHR1EHMT2 | |
| Trifluoroacetic Acid SCHEMBL6466263 | 0.88 | MAPT (0.40) | WHR1AURKAALDH1A1KDM4EMAPT | |
| Trifluoroacetic Acid SCHEMBL6467465 | 0.88 | MAPT (0.39) | WHR1AURKAALDH1A1KDM4EMAPT | |
| Trifluoroacetic Acid SCHEMBL6469209 | 0.88 | RET (0.43) | KDM4EEHMT2PDGFRB | |
| Trifluoroacetic Acid SCHEMBL6471240 | 0.88 | RET (0.43) | WHR1AURKAALDH1A1KDM4EEHMT2 | |
| Trifluoroacetic Acid SCHEMBL6470209 | 0.88 | MAPT (0.39) | WHR1AURKAALDH1A1KDM4EMAPT | |
| Trifluoroacetic Acid SCHEMBL6465517 | 0.88 | KDM4E (0.40) | WHR1AURKAALDH1A1KDM4EMAPT | |
| Trifluoroacetic Acid SCHEMBL6470128 | 0.88 | PDK1 (0.41) | WHR1AURKAALDH1A1KDM4EMAPT | |
| SCHEMBL6469099 | 0.88 | AURKA (0.36) | WHR1AURKAALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | claimed |
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | WHR1 4034/4885AURKA 1070/4885ALDH1A1 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.