Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KIF5B | P33176 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6469161 | 0.92 | PDK2 (0.39) | HRH3PDK2AVPR1BLTA4HMCHR1 | |
| Trifluoroacetic Acid SCHEMBL6467099 | 0.91 | RET (0.40) | HRH3PDK2AVPR1BKDM4ELTA4H | |
| Trifluoroacetic Acid SCHEMBL6470902 | 0.90 | HRH3 (0.42) | HRH3AVPR1BKCNH2DRD3 | |
| SCHEMBL6469230 | 0.90 | PDK2 (0.37) | HRH3PDK2AVPR1BKDM4ELTA4H | |
| Trifluoroacetic Acid SCHEMBL6469939 | 0.88 | AVPR1B (0.43) | AVPR1BAURKBHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL6469283 | 0.87 | HRH3 (0.39) | HRH3KDM4EMEN1PSMD14APAF1 | |
| Trifluoroacetic Acid SCHEMBL6470080 | 0.86 | KDM4E (0.39) | KDM4EMEN1PSMD14APAF1MITF | |
| Trifluoroacetic Acid SCHEMBL6469071 | 0.86 | F2 (0.37) | HRH3KDM4EMEN1PSMD14APAF1 | |
| Trifluoroacetic Acid SCHEMBL6467382 | 0.85 | ALDH1A1 (0.38) | KDM4EMEN1PSMD14APAF1MITF | |
| SCHEMBL6469171 | 0.82 | PDK2 (0.38) | HRH3PDK2AVPR1BLTA4HMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | claimed |
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | HRH3 638/4885PDK2 1267/4885AVPR1B 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.