Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 5/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 6/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6469939 | 0.93 | AVPR1B (0.43) | AVPR1B | |
| Trifluoroacetic Acid SCHEMBL6469150 | 0.90 | RET (0.42) | HRH3KCNH2AVPR1BESR1ESR2 | |
| Trifluoroacetic Acid SCHEMBL6469223 | 0.90 | HRH3 (0.38) | HRH3KCNH2AVPR1BDRD3 | |
| Trifluoroacetic Acid SCHEMBL6469209 | 0.89 | RET (0.43) | HRH3KCNH2AVPR1BESR1ESR2 | |
| Trifluoroacetic Acid SCHEMBL6467382 | 0.89 | ALDH1A1 (0.38) | — | |
| SCHEMBL6470906 | 0.89 | HRH3 (0.39) | HRH3KCNH2AVPR1BSRCTERT | |
| Trifluoroacetic Acid SCHEMBL6470080 | 0.88 | KDM4E (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL6469071 | 0.88 | F2 (0.37) | HRH3KCNH2ESR1PDGFRB | |
| Trifluoroacetic Acid SCHEMBL6468678 | 0.86 | HRH3 (0.46) | HRH3KCNH2AVPR1B | |
| Trifluoroacetic Acid SCHEMBL6470895 | 0.85 | MEN1 (0.37) | ESR1ESR2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | claimed |
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | REPLIDYNE, INC. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124562-A1 | Bis-quinazoline compounds for the treatment of bacterial infections | POLI, POLK, POLB | HRH3 638/4885KCNH2 3344/4885AVPR1B 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.