Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469243 | 1.00 | NPC1 (0.37) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL918379 | 1.00 | NPC1 (0.37) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6450483 | 0.84 | PPARG (0.41) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6450486 | 0.84 | PPARG (0.41) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6311612 | 0.84 | PPARG (0.41) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL918394 | 0.83 | PPARG (0.51) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6469802 | 0.83 | PPARG (0.51) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL919014 | 0.83 | NFE2L2 (0.46) | PPARGPPARAMAOAMAOBTUBB1 | |
| SCHEMBL6469970 | 0.80 | PPARG (0.53) | PPARGPPARAMAOAMAOBPTGS2 | |
| SCHEMBL919514 | 0.80 | PPARG (0.53) | PPARGPPARAMAOAMAOBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554236-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | Welichem Biotech Inc. (CA) | 2005-07-20 | — | — | EP | claimed |
| WO-2004031117-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | WELICHEM BIOTECH INC. (CA) | 2004-04-15 | — | — | WO | claimed |