Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.52 |
| ▸ | LOX | P28300 | 4/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011962 | 0.82 | HRH3 (0.51) | HRH3LOXHRH2HRH1MEN1 | |
| SCHEMBL56319 | 0.80 | LOX (0.57) | HRH3LOXMEN1KMT2AGAA | |
| SCHEMBL2921597 | 0.80 | ESR1 (0.58) | HRH3LOXMEN1KMT2AGAA | |
| SCHEMBL13604236 | 0.79 | KMT2A (0.71) | LOXMEN1KMT2ALTA4H | |
| SCHEMBL2922255 | 0.78 | ESR1 (0.56) | LOXMEN1KMT2AGAALTA4H | |
| SCHEMBL14476103 | 0.77 | MEN1 (0.73) | LOXMEN1KMT2ALTA4H | |
| SCHEMBL6837022 | 0.76 | ALDH1A1 (0.51) | HRH3LOXMEN1KMT2AKCNH2 | |
| SCHEMBL8412814 | 0.76 | ESR1 (0.52) | LOXMEN1KMT2AGAATSHR | |
| SCHEMBL8423201 | 0.76 | SMN1; SMN2 (0.60) | HRH3LOXKMT2AGAAMAPT | |
| SCHEMBL12015819 | 0.74 | LOX (0.51) | LOXMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572650-A1 | NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | AstraZeneca AB (SE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056773-A1 | NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |